HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	27634302, 36517590
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045202 - synapse GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 245 Hs			1 746
+	Hs
		909600 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		927084 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		683376 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		904608 1433G_HUMAN (1-242): 5.48e-105: 305: 70.33		EZH2_HUMAN (1-746): 0: 862: 100.00
+	At
		965377 14332_ARATH (3-243): 8.65e-144: 404: 61.22		EZA1_ARATH (237-733): 1.14e-103: 339: 28.50
+	At
		955871 14332_ARATH (3-243): 8.65e-144: 404: 61.22		CLF_ARATH (248-733): 3.24e-95: 317: 28.36
+	At
		788596 14333_ARATH (3-243): 8e-143: 401: 61.63		SUVH3_ARATH (377-730): 1.19e-79: 270: 16.22
+	Hs
		982458 1433F_HUMAN (2-242): 7.16e-106: 307: 71.43		NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42
+	Hs
		909465 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		646818 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		926950 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		683283 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		683979 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		165635 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71
+	Hs
		975227 1433F_HUMAN (2-242): 7.16e-106: 307: 71.43		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		904464 1433G_HUMAN (1-242): 5.48e-105: 305: 70.33		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54