HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: CRTC2 (Q53ET0)
CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2)
Gene: CRTC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.745

Property	Details
Experiments	15454081, 17353931, 33961781, 35271311, 36931259, 23444366, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 693
+	Hs
		909630 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		CRTC2_HUMAN (1-693): 1.02e-75: 259: 100.00
+	Hs
		927110 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		CRTC2_HUMAN (1-693): 1.02e-75: 259: 100.00
+	Hs
		683398 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		CRTC2_HUMAN (1-693): 1.02e-75: 259: 100.00
+	Mm
		910268 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		CRTC1_MOUSE (14-692): 1.51e-43: 168: 34.43
+	Hs
		909699 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		CRTC3_HUMAN (10-692): 3.58e-28: 122: 34.10
+	Hs
		647017 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		CRTC3_HUMAN (10-692): 3.58e-28: 122: 34.10
+	Hs
		909700 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		CRTC1_HUMAN (14-692): 3.45e-25: 113: 31.41
+	Hs
		927184 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		CRTC3_HUMAN (10-692): 3.58e-28: 122: 34.10
+	Rn
		910356 1433E_RAT (2-243): 1.31e-144: 406: 63.53		CRTC1_RAT (14-692): 2.63e-24: 109: 28.49
+	Hs
		647018 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		CRTC1_HUMAN (14-692): 3.45e-25: 113: 31.41
+	Hs
		927185 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		CRTC1_HUMAN (14-692): 3.45e-25: 113: 31.41
+	Hs
		909712 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		OTOG_HUMAN (75-636): 2.31e-18: 92.6: 15.12
+	Hs
		297821 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		K0754_HUMAN (6-347): 2.26e-17: 89.1: 12.28
+	Hs
		647025 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		OTOG_HUMAN (75-636): 2.31e-18: 92.6: 15.12
+	Hs
		927196 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		OTOG_HUMAN (75-636): 2.31e-18: 92.6: 15.12
+	Hs
		297824 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		K0754_HUMAN (6-347): 2.26e-17: 89.1: 12.28
+	Hs
		297815 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		K0754_HUMAN (6-347): 2.26e-17: 89.1: 12.28
+	Hs
		909937 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		CIC_HUMAN (88-691): 4e-09: 62.2: 9.81
+	Hs
		647206 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		CIC_HUMAN (88-691): 4e-09: 62.2: 9.81
+	Hs
		927430 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		CIC_HUMAN (88-691): 4e-09: 62.2: 9.81