HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.751

Property	Details
Experiments	20642453, 24510904, 29519959, 31046837, 35266954, 22612223, 24351927, unassigned1853, 23075850, 24947832
Identification Methods	affinity chromatography technology, pull down, fluorescence polarization spectroscopy, anti tag coimmunoprecipitation, surface plasmon resonance
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0044325 - transmembrane transporter binding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 2527
+	Hs
		909643 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Mm
		910249 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	Mm
		926794 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	Mm
		933123 1433T_MOUSE (1-245): 2.96e-141: 397: 99.59		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	At
		186958 14332_ARATH (3-243): 8.65e-144: 404: 61.22		BRI1_ARATH (774-1520): 4.76e-120: 414: 14.52
+	Hs
		788960 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MATK_HUMAN (1683-2160): 3.41e-106: 352: 20.43
+	Hs
		782766 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74
+	At
		965327 14332_ARATH (3-243): 8.65e-144: 404: 61.22		PBS1_ARATH (1881-2133): 6.95e-85: 288: 28.21
+	At
		965369 14332_ARATH (3-243): 8.65e-144: 404: 61.22		CLV1_ARATH (1161-1721): 1.59e-67: 251: 13.64
+	Zm
		22560 B6U284_MAIZE (1-243): 2.35e-143: 403: 59.92		A0A1D6I257_MAIZE (1063-1522): 4.27e-62: 234: 17.91
+	Hs
		910166 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SHOC2_HUMAN (944-1353): 1.23e-60: 222: 22.27
+	At
		788640 14333_ARATH (3-243): 8e-143: 401: 61.63		EMS1_ARATH (835-1129): 8.7e-53: 207: 16.10
+	At
		788442 14331_ARATH (3-242): 2.67e-142: 400: 61.07		EMS1_ARATH (835-1129): 8.7e-53: 207: 16.10
+	Hs
		909438 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		M3K9_HUMAN (1874-2136): 3.07e-24: 114: 32.38
+	Hs
		909462 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		M3K10_HUMAN (1864-2136): 2.39e-23: 110: 32.20
+	Hs
		201290 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Hs
		646793 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		M3K9_HUMAN (1874-2136): 3.07e-24: 114: 32.38
+	Hs
		646816 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		M3K10_HUMAN (1864-2136): 2.39e-23: 110: 32.20
+	At
		965375 14332_ARATH (3-243): 8.65e-144: 404: 61.22		BRL2_ARATH (1470-1771): 1.68e-09: 65.8: 10.33
+	At
		788683 14333_ARATH (3-243): 8e-143: 401: 61.63		BRL2_ARATH (1470-1771): 1.68e-09: 65.8: 10.33