HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: SPD2A (Q5TCZ1)
SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)
Gene: SH3PXD2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	33961781, 35271311, 36931259, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1133
+	Hs
		909656 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SPD2A_HUMAN (1-1133): 5.76e-173: 541: 100.00
+	Hs
		927142 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		SPD2A_HUMAN (1-1133): 5.76e-173: 541: 100.00
+	Hs
		683422 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		SPD2A_HUMAN (1-1133): 5.76e-173: 541: 100.00
+	Mm
		292560 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		SPD2A_MOUSE (1-1133): 8.37e-166: 522: 91.00
+	Hs
		909849 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SH3R3_HUMAN (384-1130): 4.05e-32: 137: 11.21
+	Hs
		909634 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SH319_HUMAN (139-558): 5.95e-22: 104: 12.62
+	Hs
		646951 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		SH319_HUMAN (139-558): 5.95e-22: 104: 12.62
+	Hs
		927118 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		SH319_HUMAN (139-558): 5.95e-22: 104: 12.62
+	Hs
		909744 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SH3R1_HUMAN (314-1130): 5.57e-18: 91.9: 8.98
+	Hs
		683401 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		SH319_HUMAN (139-558): 5.95e-22: 104: 12.62
+	Hs
		647055 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		SH3R1_HUMAN (314-1130): 5.57e-18: 91.9: 8.98
+	Hs
		927227 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		SH3R1_HUMAN (314-1130): 5.57e-18: 91.9: 8.98
+	Hs
		683498 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		SH3R1_HUMAN (314-1130): 5.57e-18: 91.9: 8.98
+	Hs
		537601 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		NCF1_HUMAN (414-661): 2.59e-14: 78.2: 15.50
+	Hs
		909551 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ARHG7_HUMAN (744-985): 6.08e-10: 65.5: 14.62
+	Hs
		909706 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		DNMBP_HUMAN (790-1131): 3.26e-09: 63.6: 11.77
+	Hs
		647023 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		DNMBP_HUMAN (790-1131): 3.26e-09: 63.6: 11.77
+	Mm
		926883 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		ARHG7_MOUSE (778-1042): 8.56e-09: 62.1: 14.39
+	Hs
		927191 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		DNMBP_HUMAN (790-1131): 3.26e-09: 63.6: 11.77
+	Hs
		683469 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		DNMBP_HUMAN (790-1131): 3.26e-09: 63.6: 11.77