HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: MARK2 (Q7KZI7)
Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)
Gene: MARK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.757

Property	Details
Experiments	35271311, 32707033, 36736316, 19553522, 19011111, 17353931, 33961781, 36931259, 15161933, 28514442
Identification Methods	affinity chromatography technology, far western blotting, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 788
+	Hs
		909730 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Mm
		910234 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		MARK2_MOUSE (1-788): 0: 764: 96.57
+	Xl
		223345 O57468_XENLA (2-243): 4.53e-144: 404: 64.75		Q8QGV3_XENLA (3-788): 0: 730: 82.70
+	Hs
		647862 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Mm
		910231 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		MARK3_MOUSE (3-788): 0: 653: 59.90
+	Hs
		910106 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MARK1_HUMAN (3-788): 0: 644: 63.22
+	Mm
		910318 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		MARK1_MOUSE (3-788): 0: 642: 64.21
+	Xl
		223344 O57468_XENLA (2-243): 4.53e-144: 404: 64.75		Q804T2_XENLA (3-788): 0: 627: 57.16
+	Dm
		90534 1433E_DROME (2-242): 6.77e-143: 401: 65.02		E1JGN0_DROME (3-788): 0: 586: 47.55
+	Hs
		909916 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MARK4_HUMAN (3-788): 0: 572: 48.20
+	Mm
		910308 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		MARK4_MOUSE (3-788): 0: 572: 48.33
+	Hs
		909567 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MELK_HUMAN (44-788): 7.75e-161: 483: 25.03
+	Hs
		910013 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SIK2_HUMAN (34-733): 3.78e-144: 448: 31.08
+	Hs
		910071 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SNRK_HUMAN (48-787): 1.06e-145: 448: 23.85
+	Hs
		883214 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SIK1_HUMAN (31-679): 4.27e-140: 434: 32.98
+	Rn
		871214 1433E_RAT (2-243): 1.31e-144: 406: 63.53		AAPK1_RAT (31-560): 2.85e-141: 429: 30.00
+	Mm
		910272 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		BRSK2_MOUSE (34-481): 8.59e-138: 426: 36.60
+	Hs
		909507 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		AAPK1_HUMAN (31-560): 4.31e-139: 424: 30.37
+	Hs
		909786 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		BRSK2_HUMAN (43-481): 4.15e-137: 424: 37.11
+	Hs
		910187 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SIK3_HUMAN (50-361): 5.13e-110: 366: 58.44