HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: HDAC7 (Q8WUI4)
Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-)
Gene: HDAC7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.747

Property	Details
Experiments	16980613, 16956611, 17369396, 23752268, 33961781, 15161933, 28514442
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0071889 - 14-3-3 protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 952
+	Hs
		909856 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		HDAC7_HUMAN (1-952): 0: 1051: 100.00
+	Hs
		927340 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		HDAC7_HUMAN (1-952): 0: 1051: 100.00
+	Mm
		910299 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		HDAC7_MOUSE (1-952): 0: 986: 85.42
+	Hs
		880661 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		HDAC4_HUMAN (20-939): 0: 958: 48.44
+	Hs
		646756 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		HDAC4_HUMAN (20-939): 0: 958: 48.44
+	Hs
		880673 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		HDAC4_HUMAN (20-939): 0: 958: 48.44
+	Hs
		910144 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		HDAC9_HUMAN (20-892): 0: 869: 43.28
+	Mm
		910239 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		Q3UJF1_MOUSE (20-950): 0: 851: 41.88
+	Hs
		910173 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		HDAC5_HUMAN (20-950): 0: 850: 41.21
+	Hs
		647390 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		HDAC5_HUMAN (20-950): 0: 850: 41.21
+	Mm
		910352 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		HDAC5_MOUSE (20-950): 0: 842: 41.49
+	Mm
		933120 1433T_MOUSE (1-245): 2.96e-141: 397: 99.59		Q3UJF1_MOUSE (20-950): 0: 851: 41.88
+	Mm
		933148 1433T_MOUSE (1-245): 2.96e-141: 397: 99.59		HDAC5_MOUSE (20-950): 0: 842: 41.49
+	Hs
		909530 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		HDAC1_HUMAN (510-916): 1.27e-170: 507: 21.91
+	Hs
		177251 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		HDAC3_HUMAN (518-951): 2.59e-161: 481: 20.00
+	Hs
		177204 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		HDAC3_HUMAN (518-951): 2.59e-161: 481: 20.00
+	Hs
		910121 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		HDAC6_HUMAN (443-951): 2.96e-115: 383: 30.33
+	Hs
		647353 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		HDAC6_HUMAN (443-951): 2.96e-115: 383: 30.33
+	Dm
		664668 1433Z_DROME (1-245): 3.68e-141: 397: 77.14		Q9VYF3_DROME (50-490): 2.74e-68: 250: 20.08
+	Dm
		664611 1433Z_DROME (1-245): 3.68e-141: 397: 77.14		Q59E49_DROME (50-490): 9.5e-58: 218: 18.40