HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.689

Property	Details
Experiments	34294877, 21900244, 36931259, 23444366
Identification Methods	unspecified method, affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0044325 - transmembrane transporter binding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 975
+	Hs
		909930 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		927423 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Mm
		910302 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		NED4L_MOUSE (17-975): 0: 1014: 98.02
+	Mm
		93264 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		E9PXB7_MOUSE (122-975): 0: 863: 95.79
+	Mm
		93266 1433T_MOUSE (1-245): 2.96e-141: 397: 99.59		E9PXB7_MOUSE (122-975): 0: 863: 95.79
+	Mm
		808343 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		NEDD4_MOUSE (12-975): 0: 794: 55.19
+	Hs
		647267 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		647191 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		808077 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125318 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		646713 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		808081 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125169 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		125351 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		909745 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		927228 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	At
		788566 14333_ARATH (3-243): 8e-143: 401: 61.63		UPL2_ARATH (556-972): 1.55e-158: 520: 39.16
+	Rn
		910358 1433E_RAT (2-243): 1.31e-144: 406: 63.53		NEDD4_RAT (13-452): 2.05e-63: 233: 46.82
+	Rn
		933150 1433T_RAT (1-245): 2.96e-141: 397: 99.59		NEDD4_RAT (13-452): 2.05e-63: 233: 46.82
+	Hs
		647296 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71