HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: TESK2 (Q96S53)
Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2)
Gene: TESK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	32707033, 33961781, 36931259, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 571
+	Hs
		909940 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		TESK2_HUMAN (1-571): 5.03e-163: 478: 100.00
+	Hs
		927432 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		TESK2_HUMAN (1-571): 5.03e-163: 478: 100.00
+	Hs
		683647 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		TESK2_HUMAN (1-571): 5.03e-163: 478: 100.00
+	At
		965327 14332_ARATH (3-243): 8.65e-144: 404: 61.22		PBS1_ARATH (6-401): 1.39e-132: 396: 21.45
+	Hs
		684284 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		TESK2_HUMAN (1-571): 5.03e-163: 478: 100.00
+	Hs
		909593 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		TESK1_HUMAN (41-558): 1.25e-125: 384: 47.62
+	Hs
		982411 1433F_HUMAN (2-242): 7.16e-106: 307: 71.43		TESK2_HUMAN (1-571): 5.03e-163: 478: 100.00
+	At
		788521 14333_ARATH (3-243): 8e-143: 401: 61.63		PBL9_ARATH (15-366): 3.69e-125: 375: 20.98
+	At
		965320 14332_ARATH (3-243): 8.65e-144: 404: 61.22		BAK1_ARATH (14-356): 3.39e-121: 372: 23.14
+	Hs
		683370 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		TESK1_HUMAN (41-558): 1.25e-125: 384: 47.62
+	Hs
		909494 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MERTK_HUMAN (61-437): 2.75e-100: 327: 25.00
+	Hs
		646846 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		MERTK_HUMAN (61-437): 2.75e-100: 327: 25.00
+	Hs
		683304 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		MERTK_HUMAN (61-437): 2.75e-100: 327: 25.00
+	Hs
		684054 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		TESK1_HUMAN (41-558): 1.25e-125: 384: 47.62
+	Hs
		982038 1433F_HUMAN (2-242): 7.16e-106: 307: 71.43		TESK1_HUMAN (41-558): 1.25e-125: 384: 47.62
+	Hs
		863759 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		LIMK1_HUMAN (62-312): 5.56e-66: 228: 44.40
+	Hs
		863760 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		LIMK1_HUMAN (62-312): 5.56e-66: 228: 44.40
+	Hs
		863816 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		LIMK2_HUMAN (62-318): 8.84e-61: 214: 40.86
+	Hs
		683916 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		LIMK1_HUMAN (62-312): 5.56e-66: 228: 44.40
+	Hs
		683917 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		LIMK2_HUMAN (62-318): 8.84e-61: 214: 40.86