HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	33961781, 36931259, 21555462, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 400
+	Hs
		910005 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Mm
		910339 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Hs
		808460 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		646714 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		125318 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Hs
		647191 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		ITCH_HUMAN (37-356): 2.6e-60: 211: 14.83
+	Hs
		125169 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Hs
		909790 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88
+	Hs
		910022 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SAV1_HUMAN (2-252): 3.57e-48: 169: 15.89
+	Hs
		909674 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		WWC2_HUMAN (121-264): 2.83e-43: 163: 15.97
+	Hs
		647091 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88
+	Dm
		955002 1433E_DROME (2-242): 6.77e-143: 401: 65.02		YAP1_DROME (17-223): 5.05e-46: 164: 22.80
+	Hs
		646997 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		WWC2_HUMAN (121-264): 2.83e-43: 163: 15.97
+	Mm
		910302 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		NED4L_MOUSE (129-395): 4.63e-24: 106: 11.96
+	Hs
		808077 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00
+	Mm
		93264 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		E9PXB7_MOUSE (129-395): 7.76e-23: 102: 12.68
+	Rn
		910358 1433E_RAT (2-243): 1.31e-144: 406: 63.53		NEDD4_RAT (129-328): 3.12e-22: 100: 11.65
+	Mm
		808343 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		NEDD4_MOUSE (129-328): 8.42e-21: 96.6: 10.44
+	Hs
		646713 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00
+	Hs
		909930 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		NED4L_HUMAN (164-352): 3.03e-13: 73.5: 13.20