HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: MYLK2 (Q9H1R3)
Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18)
Gene: MYLK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	31980649, 20618440, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0045202 - synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 596
+	Hs
		910017 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MYLK2_HUMAN (1-596): 0: 528: 100.00
+	Hs
		927515 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		MYLK2_HUMAN (1-596): 0: 528: 100.00
+	Hs
		909621 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MYLK3_HUMAN (10-588): 3.51e-137: 420: 42.81
+	At
		965291 14332_ARATH (3-243): 8.65e-144: 404: 61.22		CDPK1_ARATH (128-580): 4.38e-140: 421: 25.33
+	At
		802001 14334_ARATH (3-243): 2.7e-141: 398: 61.63		CDPK1_ARATH (128-580): 4.38e-140: 421: 25.33
+	Hs
		681770 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		AKT1_HUMAN (172-588): 3.1e-135: 404: 21.43
+	Hs
		910174 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		KCC2A_HUMAN (271-596): 2.76e-134: 402: 32.33
+	Hs
		909532 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		KCC2D_HUMAN (280-596): 5.43e-133: 399: 30.53
+	Mm
		515221 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		KCC2A_MOUSE (271-581): 3.42e-134: 402: 32.38
+	Hs
		681776 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		AKT1_HUMAN (172-588): 3.1e-135: 404: 21.43
+	Hs
		647391 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		KCC2A_HUMAN (271-596): 2.76e-134: 402: 32.33
+	Mm
		926819 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		KCC2D_MOUSE (280-596): 5.43e-133: 399: 30.53
+	Hs
		683826 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		KCC2A_HUMAN (271-596): 2.76e-134: 402: 32.33
+	Hs
		910132 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		DAPK2_HUMAN (289-584): 5.32e-71: 234: 39.67
+	Hs
		200101 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		DAPK3_HUMAN (271-566): 4.44e-67: 227: 40.06
+	Hs
		646746 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		DAPK1_HUMAN (271-540): 5.04e-64: 230: 42.09
+	Hs
		200087 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		DAPK3_HUMAN (271-566): 4.44e-67: 227: 40.06
+	Hs
		200089 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		DAPK3_HUMAN (271-566): 4.44e-67: 227: 40.06
+	Hs
		647151 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		TITIN_HUMAN (289-591): 2.8e-56: 207: 35.97
+	Hs
		927352 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		TITIN_HUMAN (289-591): 2.8e-56: 207: 35.97