HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: PAK6 (Q9NQU5)
Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)
Gene: PAK6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	17353931, 32707033
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 681
+	Hs
		910063 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		PAK6_HUMAN (1-681): 0: 641: 100.00
+	Hs
		910114 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		PAK5_HUMAN (1-676): 1.65e-174: 516: 44.51
+	Hs
		647344 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		PAK5_HUMAN (1-676): 1.65e-174: 516: 44.51
+	Hs
		330944 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		PAK4_HUMAN (1-675): 1.1e-156: 466: 43.79
+	Hs
		330862 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		PAK4_HUMAN (1-675): 1.1e-156: 466: 43.79
+	Hs
		330968 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		PAK4_HUMAN (1-675): 1.1e-156: 466: 43.79
+	Hs
		909458 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		KPCE_HUMAN (263-677): 1.74e-130: 404: 20.55
+	Hs
		681770 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		AKT1_HUMAN (349-680): 1.47e-131: 398: 23.10
+	Hs
		646812 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		KPCE_HUMAN (263-677): 1.74e-130: 404: 20.55
+	Hs
		926942 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		KPCE_HUMAN (263-677): 1.74e-130: 404: 20.55
+	At
		965360 14332_ARATH (3-243): 8.65e-144: 404: 61.22		CIPKC_ARATH (387-661): 2.36e-131: 397: 25.62
+	At
		788672 14333_ARATH (3-243): 8e-143: 401: 61.63		CIPKC_ARATH (387-661): 2.36e-131: 397: 25.62
+	At
		1280891 14337_ARATH (2-243): 2.78e-142: 400: 60.32		CIPKC_ARATH (387-661): 2.36e-131: 397: 25.62
+	Hs
		681776 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		AKT1_HUMAN (349-680): 1.47e-131: 398: 23.10
+	Hs
		568616 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		KAPCA_HUMAN (384-680): 1.08e-129: 388: 24.44
+	Hs
		568620 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		KAPCA_HUMAN (384-680): 1.08e-129: 388: 24.44
+	Hs
		909502 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		STK4_HUMAN (402-671): 1.41e-122: 375: 38.97
+	Hs
		909512 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		STK3_HUMAN (387-671): 3.06e-121: 372: 37.59
+	Hs
		646852 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		STK4_HUMAN (402-671): 1.41e-122: 375: 38.97
+	Hs
		646859 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		STK3_HUMAN (387-671): 3.06e-121: 372: 37.59