HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: HDAC5 (Q9UQL6)
Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
Gene: HDAC5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.749

Property	Details
Experiments	33961781, 22649097, 15367659, 20716686, 21081666, 23752268, 23393134, 28514442
Identification Methods	affinity chromatography technology, unspecified method, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1122
+	Hs
		910173 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		HDAC5_HUMAN (1-1122): 0: 727: 100.00
+	Mm
		910239 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		Q3UJF1_MOUSE (1-1122): 0: 717: 92.71
+	Mm
		910352 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		HDAC5_MOUSE (1-1122): 0: 713: 92.17
+	Mm
		933120 1433T_MOUSE (1-245): 2.96e-141: 397: 99.59		Q3UJF1_MOUSE (1-1122): 0: 717: 92.71
+	Mm
		933148 1433T_MOUSE (1-245): 2.96e-141: 397: 99.59		HDAC5_MOUSE (1-1122): 0: 713: 92.17
+	Hs
		880661 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		646756 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		880673 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		910144 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		HDAC9_HUMAN (25-1055): 0: 608: 56.33
+	Hs
		909856 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Hs
		647138 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Hs
		927340 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Dm
		664668 1433Z_DROME (1-245): 3.68e-141: 397: 77.14		Q9VYF3_DROME (113-1121): 4.18e-149: 480: 30.31
+	Hs
		909530 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Dm
		664611 1433Z_DROME (1-245): 3.68e-141: 397: 77.14		Q59E49_DROME (135-1121): 3.58e-143: 463: 30.18
+	Mm
		910299 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		HDAC7_MOUSE (191-1122): 3.04e-139: 446: 37.55
+	Hs
		177251 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		HDAC3_HUMAN (679-1119): 5.97e-144: 441: 21.57
+	Hs
		177204 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		HDAC3_HUMAN (679-1119): 5.97e-144: 441: 21.57
+	Hs
		910121 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97
+	Hs
		647353 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97