HitPredict

Interactor 1: AP2B (P27351)
AP-2 complex subunit beta (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Clathrin assembly protein large beta chain)
Gene: APL1

Interactor 2: AP2S (Q00381)
AP-2 complex subunit sigma (Adaptin small chain) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: APS2

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.854

Property	Details
Experiments	10564262, 16554755, 19822444
Identification Methods	coimmunoprecipitation, affinity chromatography technology, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0005935 - cellular bud neck GO:0006886 - intracellular protein transport GO:0006897 - endocytosis GO:0016192 - vesicle-mediated transport GO:0030122 - AP-2 adaptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 700 Sc			1 147
+	Hs
		926066 AP2B1_HUMAN (1-699): 0: 583: 27.89		AP1M2_HUMAN (1-147): 6.51e-46: 155: 16.89
+	Hs
		925992 AP2B1_HUMAN (1-699): 0: 583: 27.89		AP1M1_HUMAN (1-142): 6.09e-45: 153: 14.79
+	Hs
		880408 AP2B1_HUMAN (1-699): 0: 583: 27.89		AP1S2_HUMAN (3-147): 1.37e-46: 150: 40.00
+	Hs
		903681 AP2B1_HUMAN (1-699): 0: 583: 27.89		AP1S1_HUMAN (3-147): 4.12e-46: 148: 37.93
+	Hs
		925978 AP2B1_HUMAN (1-699): 0: 583: 27.89		AP1S3_HUMAN (3-147): 7.59e-44: 143: 42.76
+	Hs
		864065 AP2B1_HUMAN (1-699): 0: 583: 27.89		AP2S1_HUMAN (3-147): 5.37e-43: 140: 48.97
+	Hs
		1014107 AP1B1_HUMAN (1-700): 0: 556: 26.69		AP1M2_HUMAN (1-147): 6.51e-46: 155: 16.89
+	Hs
		1014074 AP1B1_HUMAN (1-700): 0: 556: 26.69		AP1M1_HUMAN (1-142): 6.09e-45: 153: 14.79
+	Hs
		880409 AP1B1_HUMAN (1-700): 0: 556: 26.69		AP1S2_HUMAN (3-147): 1.37e-46: 150: 40.00
+	Hs
		903682 AP1B1_HUMAN (1-700): 0: 556: 26.69		AP1S1_HUMAN (3-147): 4.12e-46: 148: 37.93
+	Hs
		1014066 AP1B1_HUMAN (1-700): 0: 556: 26.69		AP1S3_HUMAN (3-147): 7.59e-44: 143: 42.76
+	Hs
		864070 AP1B1_HUMAN (1-700): 0: 556: 26.69		AP2S1_HUMAN (3-147): 5.37e-43: 140: 48.97
+	Ce
		725358 Q9N4F3_CAEEL (1-657): 0: 543: 28.29		AP1M_CAEEL (1-142): 1.87e-43: 149: 18.31
+	Dm
		1096906 Q24253_DROME (1-634): 0: 548: 28.64		Q9VDC3_DROME (3-147): 3.36e-43: 141: 48.28
+	At
		1196570 APBLB_ARATH (3-699): 0: 553: 27.71		AP2S_ARATH (3-147): 1.28e-40: 134: 48.97
+	Zm
		30064 A0A1D6K3D9_MAIZE (45-699): 1.29e-175: 525: 26.75		Q9MAY9_MAIZE (2-141): 1.7e-42: 140: 17.02
+	Mm
		612130 AP1G1_MOUSE (5-692): 8.86e-165: 496: 11.38		AP1M1_MOUSE (1-142): 5.37e-45: 153: 14.79
+	Hs
		212611 AP1G1_HUMAN (5-692): 3.91e-164: 494: 11.38		AP1S2_HUMAN (3-147): 1.37e-46: 150: 40.00
+	Hs
		212614 AP1G1_HUMAN (5-692): 3.91e-164: 494: 11.38		AP1S1_HUMAN (3-147): 4.12e-46: 148: 37.93
+	Hs
		212608 AP1G1_HUMAN (5-692): 3.91e-164: 494: 11.38		AP2S1_HUMAN (3-147): 5.37e-43: 140: 48.97