HitPredict

Interactor 1: MK03 (P27361)
Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
Gene: MAPK3

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.973

The method score is based on:

Property Details
Experiments 19058874, 9733512, 8226933, 34497368, 9006895, 8626767, 34965427, 11134045, 19197339
Identification Methods affinity chromatography technology, enzymatic study, pull down, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0000165 - MAPK cascade
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005739 - mitochondrion
and 22 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 379
Hs

1 393
+ Hs
+ Hs
+ At
+ Mm
+ Hs
+ Xl
+ Xl
+ At
+ Hs
+ At
+ Dm
+ At
+ At
+ At
+ At
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024