HitPredict

Interactor 1: MK03 (P27361)
Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
Gene: MAPK3

Interactor 2: DUS6 (Q16828)
Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
Gene: DUSP6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.968

The method score is based on:

Property Details
Experiments 25515236, 27880917, 27432908, 31980649, 9535927, 32707033, unassigned2173, 12840032
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains DSPc~Pkinase, Pkinase~Rhodanese
Common GO terms GO:0000165 - MAPK cascade
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0070371 - ERK1 and ERK2 cascade
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 379
Hs

1 381
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024