HitPredict

Interactor 1: MARK3 (P27448)
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)
Gene: MARK3

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.697

Property	Details
Experiments	16189514, 15778465, 36931259, 36736316
Identification Methods	two hybrid, affinity chromatography technology, proximity labelling technology, cross-linking study, tandem affinity purification, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 753 Hs			1 248
+	Hs
		647862 MARK3_HUMAN (1-753): 0: 769: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Mm
		910231 MARK3_MOUSE (1-753): 0: 763: 97.08		1433E_MOUSE (2-246): 4.41e-146: 410: 60.41
+	Hs
		647869 MARK3_HUMAN (1-753): 0: 769: 100.00		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Mm
		926780 MARK3_MOUSE (1-753): 0: 763: 97.08		1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96
+	Xl
		223344 Q804T2_XENLA (1-753): 0: 723: 88.31		O57468_XENLA (2-246): 5.73e-145: 407: 60.00
+	Hs
		646650 MARK3_HUMAN (1-753): 0: 769: 100.00		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		684157 MARK2_HUMAN (2-753): 0: 626: 59.90		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		647835 MARK3_HUMAN (1-753): 0: 769: 100.00		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		647860 MARK3_HUMAN (1-753): 0: 769: 100.00		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Mm
		975157 MARK3_MOUSE (1-753): 0: 763: 97.08		1433B_MOUSE (1-239): 3.73e-99: 290: 68.62
+	Hs
		647879 MARK3_HUMAN (1-753): 0: 769: 100.00		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Mm
		905331 MARK3_MOUSE (1-753): 0: 763: 97.08		1433G_MOUSE (1-242): 1.86e-98: 289: 65.16
+	Mm
		935481 MARK3_MOUSE (1-753): 0: 763: 97.08		1433F_MOUSE (2-242): 1.72e-96: 284: 64.20
+	Xl
		223345 Q8QGV3_XENLA (1-753): 0: 637: 59.40		O57468_XENLA (2-246): 5.73e-145: 407: 60.00
+	Hs
		909730 MARK2_HUMAN (2-753): 0: 626: 59.90		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		927214 MARK2_HUMAN (2-753): 0: 626: 59.90		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		647041 MARK2_HUMAN (2-753): 0: 626: 59.90		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		683485 MARK2_HUMAN (2-753): 0: 626: 59.90		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		904766 MARK2_HUMAN (2-753): 0: 626: 59.90		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		982193 MARK2_HUMAN (2-753): 0: 626: 59.90		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20