HitPredict

Interactor 1: MARK3 (P27448)
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)
Gene: MARK3

Interactor 2: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.752

Property	Details
Experiments	29089450, 35271311, 32707033, 36736316, 16968750, 36931259, 17979178, 20642453, 16306228
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification, pull down, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0035556 - intracellular signal transduction GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 753 Hs			1 255
+	Mm
		910231 MARK3_MOUSE (1-753): 0: 763: 97.08		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Xl
		223344 Q804T2_XENLA (1-753): 0: 723: 88.31		O57468_XENLA (1-255): 1.7e-152: 426: 96.47
+	Xl
		223345 Q8QGV3_XENLA (1-753): 0: 637: 59.40		O57468_XENLA (1-255): 1.7e-152: 426: 96.47
+	Hs
		909730 MARK2_HUMAN (2-753): 0: 626: 59.90		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Mm
		910234 MARK2_MOUSE (2-753): 0: 623: 59.12		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Mm
		910318 MARK1_MOUSE (1-753): 0: 620: 63.76		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Hs
		910106 MARK1_HUMAN (1-753): 0: 619: 62.89		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Mm
		910308 MARK4_MOUSE (1-753): 0: 613: 60.24		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Hs
		909916 MARK4_HUMAN (1-753): 0: 612: 60.24		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Dm
		90534 E1JGN0_DROME (2-753): 0: 577: 50.53		1433E_DROME (1-254): 2.95e-146: 411: 82.69
+	Hs
		909567 MELK_HUMAN (47-753): 2.32e-173: 514: 27.65		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		883214 SIK1_HUMAN (34-672): 2.85e-143: 441: 30.99		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		871354 AAPK2_HUMAN (48-544): 4.52e-145: 437: 31.77		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Sc
		419854 SNF1_YEAST (35-509): 1.38e-145: 442: 35.46		BMH2_YEAST (4-242): 1.14e-134: 382: 77.08
+	Sc
		419824 SNF1_YEAST (35-509): 1.38e-145: 442: 35.46		BMH1_YEAST (2-243): 2.43e-134: 381: 75.72
+	Hs
		910187 SIK3_HUMAN (53-364): 1.13e-113: 375: 58.13		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		910013 SIK2_HUMAN (53-364): 2.39e-107: 350: 54.89		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909786 BRSK2_HUMAN (47-500): 2.68e-79: 271: 36.11		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00