HitPredict

Interactor 1: MARK3 (P27448)
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)
Gene: MARK3

Interactor 2: RHOH (Q15669)
Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)
Gene: RHOH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 753 Hs			1 191
+	Hs
		436165 MARK3_HUMAN (1-753): 0: 769: 100.00		RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25
+	Hs
		647867 MARK3_HUMAN (1-753): 0: 769: 100.00		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		647868 MARK3_HUMAN (1-753): 0: 769: 100.00		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		564418 MARK3_HUMAN (1-753): 0: 769: 100.00		RHOQ_HUMAN (5-190): 8.15e-74: 222: 39.49
+	Hs
		647856 MARK3_HUMAN (1-753): 0: 769: 100.00		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		545213 MARK3_HUMAN (1-753): 0: 769: 100.00		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		647855 MARK3_HUMAN (1-753): 0: 769: 100.00		RAC3_HUMAN (2-171): 3.86e-72: 218: 41.81
+	Hs
		647872 MARK3_HUMAN (1-753): 0: 769: 100.00		RHOG_HUMAN (2-191): 2.32e-71: 216: 37.56
+	Hs
		647858 MARK3_HUMAN (1-753): 0: 769: 100.00		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Hs
		1076632 MARK2_HUMAN (2-753): 0: 626: 59.90		RHOH_HUMAN (1-191): 2.74e-95: 276: 100.00
+	Hs
		436371 MARK2_HUMAN (2-753): 0: 626: 59.90		RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25
+	Hs
		915778 MARK2_HUMAN (2-753): 0: 626: 59.90		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		925384 MARK2_HUMAN (2-753): 0: 626: 59.90		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		564584 MARK2_HUMAN (2-753): 0: 626: 59.90		RHOQ_HUMAN (5-190): 8.15e-74: 222: 39.49
+	Hs
		894157 MARK2_HUMAN (2-753): 0: 626: 59.90		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		545461 MARK2_HUMAN (2-753): 0: 626: 59.90		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		892447 MARK2_HUMAN (2-753): 0: 626: 59.90		RAC3_HUMAN (2-171): 3.86e-72: 218: 41.81
+	Hs
		951102 MARK2_HUMAN (2-753): 0: 626: 59.90		RHOG_HUMAN (2-191): 2.32e-71: 216: 37.56
+	Hs
		900617 MARK2_HUMAN (2-753): 0: 626: 59.90		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Hs
		894319 MARK4_HUMAN (1-753): 0: 612: 60.24		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25