HitPredict

Interactor 1: MARK3 (P27448)
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)
Gene: MARK3

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030425 - dendrite
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 753 Hs			1 822
+	Hs
		384307 MARK3_HUMAN (1-753): 0: 769: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		507867 MARK3_HUMAN (1-753): 0: 769: 100.00		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		385052 MARK2_HUMAN (2-753): 0: 626: 59.90		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		647876 MARK3_HUMAN (1-753): 0: 769: 100.00		ROR2_HUMAN (530-808): 1.44e-69: 249: 44.52
+	Hs
		434225 MARK2_HUMAN (2-753): 0: 626: 59.90		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Hs
		411417 MARK2_HUMAN (2-753): 0: 626: 59.90		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		968416 MARK2_HUMAN (2-753): 0: 626: 59.90		ROR2_HUMAN (530-808): 1.44e-69: 249: 44.52
+	Hs
		411343 AAPK2_HUMAN (48-544): 4.52e-145: 437: 31.77		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Rn
		544824 AAPK2_RAT (45-543): 7.6e-141: 427: 31.09		INSR_RAT (513-809): 7.79e-68: 247: 42.72
+	Rn
		998011 AAPK2_RAT (45-543): 7.6e-141: 427: 31.09		T2CB11_RAT (513-809): 8.4e-68: 247: 42.72