HitPredict

Interactor 1: MARK3 (P27448)
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)
Gene: MARK3

Interactor 2: RHOU (Q7L0Q8)
Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
Gene: RHOU

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 753 Hs			1 258
+	Hs
		436165 MARK3_HUMAN (1-753): 0: 769: 100.00		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		647946 MARK3_HUMAN (1-753): 0: 769: 100.00		RHOV_HUMAN (49-258): 3.82e-87: 260: 60.66
+	Hs
		647855 MARK3_HUMAN (1-753): 0: 769: 100.00		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		647872 MARK3_HUMAN (1-753): 0: 769: 100.00		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Hs
		647868 MARK3_HUMAN (1-753): 0: 769: 100.00		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		647864 MARK3_HUMAN (1-753): 0: 769: 100.00		RB11A_HUMAN (39-256): 1.13e-77: 235: 26.87
+	Hs
		647858 MARK3_HUMAN (1-753): 0: 769: 100.00		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		545213 MARK3_HUMAN (1-753): 0: 769: 100.00		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		647856 MARK3_HUMAN (1-753): 0: 769: 100.00		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		564418 MARK3_HUMAN (1-753): 0: 769: 100.00		RHOQ_HUMAN (50-221): 2.69e-66: 206: 56.40
+	Hs
		647958 MARK3_HUMAN (1-753): 0: 769: 100.00		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26
+	Hs
		436371 MARK2_HUMAN (2-753): 0: 626: 59.90		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		892447 MARK2_HUMAN (2-753): 0: 626: 59.90		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		951102 MARK2_HUMAN (2-753): 0: 626: 59.90		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Hs
		925384 MARK2_HUMAN (2-753): 0: 626: 59.90		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		914159 MARK2_HUMAN (2-753): 0: 626: 59.90		RB11A_HUMAN (39-256): 1.13e-77: 235: 26.87
+	Hs
		900617 MARK2_HUMAN (2-753): 0: 626: 59.90		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		545461 MARK2_HUMAN (2-753): 0: 626: 59.90		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		894157 MARK2_HUMAN (2-753): 0: 626: 59.90		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		564584 MARK2_HUMAN (2-753): 0: 626: 59.90		RHOQ_HUMAN (50-221): 2.69e-66: 206: 56.40