HitPredict

Interactor 1: MARK3 (P27448)
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)
Gene: MARK3

Interactor 2: KSR1 (Q8IVT5)
Kinase suppressor of Ras 1 (EC 2.7.11.1)
Gene: KSR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	29089450, 11741534, 12941695
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0106310 - protein serine kinase activity
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 753 Hs			1 923
+	Mm
		975156 MARK3_MOUSE (1-753): 0: 763: 97.08		KSR1_MOUSE (1-923): 0: 715: 84.42
+	Hs
		1057178 MELK_HUMAN (47-753): 2.32e-173: 514: 27.65		KSR1_HUMAN (1-923): 0: 765: 100.00
+	Hs
		647831 MARK3_HUMAN (1-753): 0: 769: 100.00		EPHB2_HUMAN (223-895): 5.19e-149: 469: 14.82
+	Hs
		373716 MARK3_HUMAN (1-753): 0: 769: 100.00		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Hs
		600512 MARK3_HUMAN (1-753): 0: 769: 100.00		EPHA1_HUMAN (223-917): 1.29e-138: 439: 15.72
+	Hs
		411606 MARK3_HUMAN (1-753): 0: 769: 100.00		LCK_HUMAN (591-890): 2.14e-99: 322: 24.59
+	Hs
		374431 MARK2_HUMAN (2-753): 0: 626: 59.90		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	At
		286280 KIN11_ARATH (55-446): 1.28e-148: 445: 36.68		Y2899_ARATH (97-905): 0: 591: 13.35
+	Hs
		411778 MARK2_HUMAN (2-753): 0: 626: 59.90		LCK_HUMAN (591-890): 2.14e-99: 322: 24.59