HitPredict

Interactor 1: MARK3 (P27448)
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)
Gene: MARK3

Interactor 2: UBP21 (Q9UK80)
Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21)
Gene: USP21

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	19615732, 22298430
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 753 Hs			1 565
+	Hs
		1183143 MARK2_HUMAN (2-753): 0: 626: 59.90		UBP21_HUMAN (1-565): 0: 557: 100.00
+	Hs
		1349675 MARK1_HUMAN (1-753): 0: 619: 62.89		UBP21_HUMAN (1-565): 0: 557: 100.00
+	Hs
		1296789 MARK4_HUMAN (1-753): 0: 612: 60.24		UBP21_HUMAN (1-565): 0: 557: 100.00
+	Hs
		1057209 MELK_HUMAN (47-753): 2.32e-173: 514: 27.65		UBP21_HUMAN (1-565): 0: 557: 100.00
+	Hs
		258841 O75271_HUMAN (1-395): 1.77e-145: 435: 69.39		UBP21_HUMAN (1-565): 0: 557: 100.00
+	Hs
		871383 AAPK2_HUMAN (48-544): 4.52e-145: 437: 31.77		UBP10_HUMAN (16-559): 5.8e-104: 332: 17.07
+	Sc
		419924 SNF1_YEAST (35-509): 1.38e-145: 442: 35.46		UBP8_YEAST (210-559): 9.06e-100: 312: 26.47