HitPredict

Interactor 1: MARK3 (P27448)
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)
Gene: MARK3

Interactor 2: MTCL1 (Q9Y4B5)
Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2)
Gene: MTCL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	25852190, 32707033
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 753 Hs			1 1905
+	Hs
		1183156 MARK2_HUMAN (2-753): 0: 626: 59.90		MTCL1_HUMAN (1-1905): 0: 827: 100.00
+	Hs
		1296792 MARK4_HUMAN (1-753): 0: 612: 60.24		MTCL1_HUMAN (1-1905): 0: 827: 100.00
+	Hs
		301264 MARK3_HUMAN (1-753): 0: 769: 100.00		MTCL2_HUMAN (52-1172): 3.52e-13: 77.4: 10.52
+	Hs
		301300 MARK2_HUMAN (2-753): 0: 626: 59.90		MTCL2_HUMAN (52-1172): 3.52e-13: 77.4: 10.52
+	Hs
		725223 MARK4_HUMAN (1-753): 0: 612: 60.24		MYH10_HUMAN (127-797): 1.09e-16: 89: 10.88
+	Hs
		301316 MARK4_HUMAN (1-753): 0: 612: 60.24		MTCL2_HUMAN (52-1172): 3.52e-13: 77.4: 10.52
+	Hs
		724967 MARK4_HUMAN (1-753): 0: 612: 60.24		MYH9_HUMAN (171-636): 9.75e-11: 69.3: 10.04
+	Hs
		725242 SIK2_HUMAN (53-364): 2.39e-107: 350: 54.89		MYH10_HUMAN (127-797): 1.09e-16: 89: 10.88
+	Hs
		728513 SIK2_HUMAN (53-364): 2.39e-107: 350: 54.89		MYH11_HUMAN (1036-1546): 1.17e-15: 85.9: 8.86
+	Hs
		725010 SIK2_HUMAN (53-364): 2.39e-107: 350: 54.89		MYH9_HUMAN (171-636): 9.75e-11: 69.3: 10.04