HitPredict

Interactor 1: ARNT (P27540)
Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)
Gene: ARNT

Interactor 2: AHR (P35869)
Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76)
Gene: AHR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 28514442, 8619634, 11025203, 19380484, 8631989, 26350169, 7628454, 9887096, 33961781, 19390533, 22138065, 20006590, 18096572, 12139968, 10671489, 11551916, 8621524, 10619402, 8065341, 17392787 and 9 others

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Identification Methods affinity chromatography technology, two hybrid, pull down, unspecified method, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains HLH~HLH, HLH~PAS, PAS~PAS, PAS~PAS_3, PAS~PAS_11, PAS_11~PAS_3
Common GO terms GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0004879 - nuclear receptor activity
and 12 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024