HitPredict

Interactor 1: RGRF1 (P27671)
Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (CDC25Mm) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25)
Gene: Rasgrf1

Interactor 2: RHOA (Q9QUI0)
Transforming protein RhoA (EC 3.6.5.2)
Gene: RHOA

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17993462
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RasGEF, Ras~RasGEF_N, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0043025 - neuronal cell body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1262 Mm			1 193
+	Hs
		156395 RGRF2_HUMAN (1-1262): 0: 988: 63.20		RHOA_HUMAN (1-193): 6.94e-79: 235: 99.48
+	Hs
		156397 RGRF2_HUMAN (1-1262): 0: 988: 63.20		RAC1_HUMAN (1-193): 9.27e-78: 232: 57.22
+	Hs
		156394 RGRF2_HUMAN (1-1262): 0: 988: 63.20		CDC42_HUMAN (1-193): 5.57e-75: 225: 52.33
+	Hs
		925267 RPGF1_HUMAN (501-1262): 2.42e-111: 377: 17.97		RAC1_HUMAN (1-193): 9.27e-78: 232: 57.22
+	Hs
		950984 RPGF1_HUMAN (501-1262): 2.42e-111: 377: 17.97		RHOG_HUMAN (1-193): 2.68e-75: 226: 54.40
+	Hs
		892362 RPGF1_HUMAN (501-1262): 2.42e-111: 377: 17.97		RAC3_HUMAN (1-179): 7.84e-72: 217: 57.54
+	Hs
		900985 ARHGC_HUMAN (23-970): 1.92e-99: 350: 13.06		RHOA_HUMAN (1-193): 6.94e-79: 235: 99.48
+	Hs
		900768 ARHG2_HUMAN (18-941): 1.51e-101: 348: 11.07		RHOA_HUMAN (1-193): 6.94e-79: 235: 99.48
+	Hs
		925497 ARHG2_HUMAN (18-941): 1.51e-101: 348: 11.07		RAC1_HUMAN (1-193): 9.27e-78: 232: 57.22
+	Hs
		436545 ARHGC_HUMAN (23-970): 1.92e-99: 350: 13.06		RHOC_HUMAN (1-193): 1.9e-76: 228: 92.23
+	Hs
		894523 ARHGC_HUMAN (23-970): 1.92e-99: 350: 13.06		CDC42_HUMAN (1-193): 5.57e-75: 225: 52.33
+	Hs
		167078 ARHGB_HUMAN (56-1024): 2.45e-93: 332: 10.83		RHOA_HUMAN (1-193): 6.94e-79: 235: 99.48
+	Hs
		892637 ARHGC_HUMAN (23-970): 1.92e-99: 350: 13.06		RAC3_HUMAN (1-179): 7.84e-72: 217: 57.54
+	Hs
		916029 ARHGC_HUMAN (23-970): 1.92e-99: 350: 13.06		RHOB_HUMAN (1-191): 1.08e-71: 216: 83.94
+	Hs
		167081 ARHGB_HUMAN (56-1024): 2.45e-93: 332: 10.83		RAC1_HUMAN (1-193): 9.27e-78: 232: 57.22
+	Hs
		915884 ARHG2_HUMAN (18-941): 1.51e-101: 348: 11.07		RHOB_HUMAN (1-191): 1.08e-71: 216: 83.94
+	Hs
		167063 ARHGB_HUMAN (56-1024): 2.45e-93: 332: 10.83		RHOC_HUMAN (1-193): 1.9e-76: 228: 92.23
+	Hs
		167077 ARHGB_HUMAN (56-1024): 2.45e-93: 332: 10.83		CDC42_HUMAN (1-193): 5.57e-75: 225: 52.33
+	Hs
		167079 ARHGB_HUMAN (56-1024): 2.45e-93: 332: 10.83		RHOB_HUMAN (1-191): 1.08e-71: 216: 83.94
+	Hs
		915859 RPGF6_HUMAN (624-1240): 2.44e-89: 320: 17.51		RHOB_HUMAN (1-191): 1.08e-71: 216: 83.94