HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: MRE11 (P49959)
Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)
Gene: MRE11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

The method score is based on:

Property	Details
Experiments	30179224, 18936170, 19586055, 37827155, 24332808
Identification Methods	affinity chromatography technology, x-ray crystallography, pull down, proximity labelling technology
Interaction Type	physical association, association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000723 - telomere maintenance GO:0000724 - double-strand break repair via homologous recombination GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm and 6 others more... GO:0006281 - DNA repair GO:0006310 - DNA recombination GO:0006974 - DNA damage response GO:0007004 - telomere maintenance via telomerase GO:0016605 - PML body GO:0035861 - site of double-strand break
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	616
Hs

1	708

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024