HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: PRKDC (P78527)
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)
Gene: PRKDC

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.714

Property	Details
Experiments	10064605, 12641457, 37827155, 21504906, 24332808
Identification Methods	pull down, proximity labelling technology, affinity chromatography technology, coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000723 - telomere maintenance GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 4128
+	Hs
		652700 RFA1_HUMAN (1-616): 0: 781: 100.00		TRRAP_HUMAN (2754-4128): 0: 828: 15.88
+	Hs
		650572 RFA1_HUMAN (1-616): 0: 781: 100.00		MTOR_HUMAN (2776-4127): 0: 695: 15.99
+	Hs
		651111 RFA1_HUMAN (1-616): 0: 781: 100.00		ATM_HUMAN (3218-4128): 1.84e-158: 557: 19.42
+	Hs
		651136 RFA1_HUMAN (1-616): 0: 781: 100.00		ATR_HUMAN (3377-4128): 2.05e-122: 438: 19.28
+	Sc
		607270 RFA1_YEAST (4-615): 0: 596: 31.69		TRA1_YEAST (2924-4127): 1.79e-115: 416: 14.57
+	Sc
		607258 RFA1_YEAST (4-615): 0: 596: 31.69		ATM_YEAST (3310-4127): 9.76e-104: 377: 19.71
+	Sc
		607259 RFA1_YEAST (4-615): 0: 596: 31.69		ATR_YEAST (3293-4127): 1.5e-100: 366: 15.78