HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: EXOSX (Q01780)
Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2)
Gene: EXOSC10

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	37827155, 24332808
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0046872 - metal ion binding
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 885
+	Hs
		651182 RFA1_HUMAN (1-616): 0: 781: 100.00		WRN_HUMAN (298-768): 3.9e-101: 346: 14.40
+	Hs
		652394 RFA1_HUMAN (1-616): 0: 781: 100.00		EXD2_HUMAN (243-529): 1.87e-65: 233: 16.39
+	Xl
		292761 RFA1_XENLA (2-614): 0: 692: 72.27		WRN_XENLA (298-689): 1.05e-67: 248: 12.47