HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: UBE3C (Q15386)
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
Gene: UBE3C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	37827155
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 1083
+	Hs
		650616 RFA1_HUMAN (1-616): 0: 781: 100.00		NEDD4_HUMAN (291-1081): 4.42e-178: 558: 20.10
+	Hs
		651016 RFA1_HUMAN (1-616): 0: 781: 100.00		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		651966 RFA1_HUMAN (1-616): 0: 781: 100.00		ITCH_HUMAN (594-1081): 5.52e-180: 550: 25.46
+	Hs
		651570 RFA1_HUMAN (1-616): 0: 781: 100.00		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		1235435 MEIOB_HUMAN (176-543): 7.11e-63: 216: 16.10		HECW2_HUMAN (262-1082): 0: 591: 19.91
+	Sc
		607329 RFA1_YEAST (4-615): 0: 596: 31.69		TOM1_YEAST (683-1083): 1.4e-46: 185: 32.12