HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: SMC3 (Q9UQE7)
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)
Gene: SMC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	37827155, 24332808
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0051321 - meiotic cell cycle
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 1217
+	Hs
		652371 RFA1_HUMAN (1-616): 0: 781: 100.00		SMC4_HUMAN (1-1206): 4.2e-80: 290: 16.85
+	Hs
		651210 RFA1_HUMAN (1-616): 0: 781: 100.00		SMC1A_HUMAN (2-1211): 5.21e-79: 286: 16.36
+	Hs
		311481 RFA1_HUMAN (1-616): 0: 781: 100.00		SMC2_HUMAN (1-1217): 1.65e-73: 269: 19.14
+	Sc
		607361 RFA1_YEAST (4-615): 0: 596: 31.69		SMC4_YEAST (1-1207): 1.61e-67: 252: 17.37