HitPredict

Interactor 1: PYR1 (P27708)
Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]
Gene: CAD

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004672 - protein kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0007507 - heart development
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2225 Hs			1 393
+	Hs
		625132 PYR1_HUMAN (1-2225): 0: 2858: 100.00		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		653187 PYR1_HUMAN (1-2225): 0: 2858: 100.00		MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69
+	Hs
		153087 PYR1_HUMAN (1-2225): 0: 2858: 100.00		MP2K7_HUMAN (35-375): 7.04e-61: 204: 35.49
+	Sc
		424404 PYR1_YEAST (1-2223): 0: 2271: 49.41		HOG1_YEAST (66-393): 1.71e-122: 362: 21.15
+	Hs
		625465 DPYL2_HUMAN (1397-1915): 9.65e-161: 510: 18.29		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		625428 DPYL3_HUMAN (1397-1915): 5.83e-160: 507: 18.15		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Dm
		1181315 Q7KN97_DROME (371-852): 9.53e-108: 377: 18.63		AKT1_DROME (45-389): 1.44e-121: 366: 19.49