HitPredict

Interactor 1: PYR1 (P27708)
Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]
Gene: CAD

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032868 - response to insulin GO:0032991 - protein-containing complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2225 Hs			1 594
+	Hs
		548644 PYR1_HUMAN (1-2225): 0: 2858: 100.00		VAV_HUMAN (36-594): 3.93e-139: 426: 14.11
+	Hs
		412032 PYR1_HUMAN (1-2225): 0: 2858: 100.00		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		522795 PYR1_HUMAN (1-2225): 0: 2858: 100.00		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Hs
		454801 PYR1_HUMAN (1-2225): 0: 2858: 100.00		FGR_HUMAN (441-593): 8.45e-46: 171: 18.63
+	Hs
		653181 PYR1_HUMAN (1-2225): 0: 2858: 100.00		CSK_HUMAN (454-587): 2.23e-26: 114: 23.19
+	Hs
		653221 PYR1_HUMAN (1-2225): 0: 2858: 100.00		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		522980 DPYL1_HUMAN (1397-1915): 3.53e-160: 508: 17.78		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08