HitPredict

Interactor 1: PYR1 (P27708)
Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]
Gene: CAD

Interactor 2: CDK20 (Q8IZL9)
Cyclin-dependent kinase 20 (EC 2.7.11.22) (CDK-activating kinase p42) (CAK-kinase p42) (Cell cycle-related kinase) (Cell division protein kinase 20) (Cyclin-dependent protein kinase H) (Cyclin-kinase-activating kinase p42)
Gene: CDK20

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 2225 Hs			1 346
+	Hs
		625132 PYR1_HUMAN (1-2225): 0: 2858: 100.00		CDK2_HUMAN (1-296): 5.66e-140: 400: 43.10
+	Sc
		339340 PYR1_YEAST (1-2223): 0: 2271: 49.41		CDK1_YEAST (3-291): 1.14e-124: 361: 42.71
+	Hs
		625465 DPYL2_HUMAN (1397-1915): 9.65e-161: 510: 18.29		CDK2_HUMAN (1-296): 5.66e-140: 400: 43.10
+	Hs
		625428 DPYL3_HUMAN (1397-1915): 5.83e-160: 507: 18.15		CDK2_HUMAN (1-296): 5.66e-140: 400: 43.10
+	Hs
		513551 PYC_HUMAN (367-846): 4.8e-108: 377: 18.84		CDK7_HUMAN (3-304): 2.01e-127: 370: 42.62