HitPredict

Interactor 1: PYR1 (P27708)
Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]
Gene: CAD

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30737378
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0019899 - enzyme binding GO:0031000 - response to caffeine GO:0032991 - protein-containing complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 2225 Hs			1 488
+	Hs
		653255 PYR1_HUMAN (1-2225): 0: 2858: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		653400 PYR1_HUMAN (1-2225): 0: 2858: 100.00		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04
+	Sp
		140655 PYR1_SCHPO (1-2223): 0: 2274: 49.89		PHD1_SCHPO (7-411): 0: 519: 52.56
+	Sc
		424618 PYR1_YEAST (1-2223): 0: 2271: 49.41		HOS2_YEAST (11-430): 5.02e-174: 498: 47.18
+	Hs
		679473 CPSM_HUMAN (2-1448): 0: 1504: 50.61		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		679508 CPSM_HUMAN (2-1448): 0: 1504: 50.61		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04
+	Hs
		1083129 DPYL2_HUMAN (1397-1915): 9.65e-161: 510: 18.29		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		513577 PYC_HUMAN (367-846): 4.8e-108: 377: 18.84		HDAC1_HUMAN (1-443): 0: 642: 90.07