HitPredict

Interactor 1: PYR1 (P27708)
Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]
Gene: CAD

Interactor 2: HDA11 (Q96DB2)
Histone deacetylase 11 (HD11) (EC 3.5.1.98)
Gene: HDAC11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23752268
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 2225 Hs			1 347
+	Hs
		653255 PYR1_HUMAN (1-2225): 0: 2858: 100.00		HDAC1_HUMAN (13-330): 8.87e-140: 407: 22.89
+	Hs
		653330 PYR1_HUMAN (1-2225): 0: 2858: 100.00		HDAC2_HUMAN (13-330): 4.9e-128: 376: 22.89
+	Hs
		653400 PYR1_HUMAN (1-2225): 0: 2858: 100.00		HDAC6_HUMAN (18-346): 8.68e-95: 307: 21.31
+	Sc
		424618 PYR1_YEAST (1-2223): 0: 2271: 49.41		HOS2_YEAST (3-331): 6.58e-124: 365: 21.43
+	Sp
		140655 PYR1_SCHPO (1-2223): 0: 2274: 49.89		PHD1_SCHPO (134-307): 1.94e-15: 79: 31.69
+	Hs
		679473 CPSM_HUMAN (2-1448): 0: 1504: 50.61		HDAC2_HUMAN (13-330): 4.9e-128: 376: 22.89
+	Hs
		679508 CPSM_HUMAN (2-1448): 0: 1504: 50.61		HDAC6_HUMAN (18-346): 8.68e-95: 307: 21.31
+	Hs
		1083129 DPYL2_HUMAN (1397-1915): 9.65e-161: 510: 18.29		HDAC2_HUMAN (13-330): 4.9e-128: 376: 22.89
+	Hs
		513577 PYC_HUMAN (367-846): 4.8e-108: 377: 18.84		HDAC1_HUMAN (13-330): 8.87e-140: 407: 22.89