HitPredict

Interactor 1: PYR1 (P27708)
Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]
Gene: CAD

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 2225 Hs			1 1088
+	Hs
		325638 PYR1_HUMAN (1-2225): 0: 2858: 100.00		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		653231 PYR1_HUMAN (1-2225): 0: 2858: 100.00		KPCE_HUMAN (554-1010): 1.06e-129: 413: 29.92
+	Hs
		568553 PYR1_HUMAN (1-2225): 0: 2858: 100.00		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Sc
		424649 PYR1_YEAST (1-2223): 0: 2271: 49.41		CBK1_YEAST (347-1051): 3.83e-143: 450: 29.56
+	Sc
		424307 PYR1_YEAST (1-2223): 0: 2271: 49.41		YPK1_YEAST (343-1057): 5.4e-136: 428: 20.83
+	Hs
		147313 DPYL4_HUMAN (1397-1915): 1.19e-155: 495: 18.43		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Dm
		1181315 Q7KN97_DROME (371-852): 9.53e-108: 377: 18.63		AKT1_DROME (416-1044): 5.27e-141: 439: 20.44
+	Mm
		139102 DPYL2_MOUSE (1397-1915): 5.31e-160: 508: 17.95		ROCK2_MOUSE (640-1008): 1.72e-66: 247: 37.17