HitPredict

Interactor 1: PYR1 (P27708)
Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]
Gene: CAD

Interactor 2: HDAC6 (Q9UBN7)
Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Protein deacetylase HDAC6) (EC 3.5.1.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
Gene: HDAC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35676659, 23703321
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008270 - zinc ion binding GO:0019899 - enzyme binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2225 Hs			1 1215
+	Hs
		653255 PYR1_HUMAN (1-2225): 0: 2858: 100.00		HDAC1_HUMAN (478-896): 4.05e-166: 503: 20.09
+	Hs
		653330 PYR1_HUMAN (1-2225): 0: 2858: 100.00		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		653410 PYR1_HUMAN (1-2225): 0: 2858: 100.00		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48
+	Hs
		679508 CPSM_HUMAN (2-1448): 0: 1504: 50.61		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		679473 CPSM_HUMAN (2-1448): 0: 1504: 50.61		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		1083129 DPYL2_HUMAN (1397-1915): 9.65e-161: 510: 18.29		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		513577 PYC_HUMAN (367-846): 4.8e-108: 377: 18.84		HDAC1_HUMAN (478-896): 4.05e-166: 503: 20.09