HitPredict

Interactor 1: CALR (P27797)
Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60)
Gene: CALR

Interactor 2: TMX3 (Q96JJ7)
Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3)
Gene: TMX3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Calreticulin~Thioredoxin_6
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0009986 - cell surface
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 417 Hs			1 454
+	Hs
		654668 CALX_HUMAN (20-416): 1.51e-145: 428: 34.39		TMX3_HUMAN (1-454): 2e-142: 416: 100.00
+	Hs
		653711 CALR_HUMAN (18-417): 0: 519: 100.00		ERP44_HUMAN (2-385): 5.2e-72: 234: 17.04
+	Hs
		653597 CALR_HUMAN (18-417): 0: 519: 100.00		PDIA6_HUMAN (2-365): 1.77e-62: 210: 17.06
+	Hs
		1296643 CALR3_HUMAN (1-362): 1.5e-165: 471: 51.38		ERP44_HUMAN (2-385): 5.2e-72: 234: 17.04
+	Dm
		667040 CALR_DROME (4-406): 7.43e-167: 475: 66.58		PDIA6_DROME (1-365): 1.15e-62: 211: 17.42
+	Hs
		1067796 CALR3_HUMAN (1-362): 1.5e-165: 471: 51.38		PDIA6_HUMAN (2-365): 1.77e-62: 210: 17.06
+	Hs
		654706 CALX_HUMAN (20-416): 1.51e-145: 428: 34.39		ERP44_HUMAN (2-385): 5.2e-72: 234: 17.04
+	Hs
		653491 CALR_HUMAN (18-417): 0: 519: 100.00		PDIA3_HUMAN (14-136): 6.09e-23: 103: 30.47
+	Hs
		531728 CALR_HUMAN (18-417): 0: 519: 100.00		PDIA4_HUMAN (10-130): 1.56e-21: 99.5: 25.20
+	Hs
		653575 CALR_HUMAN (18-417): 0: 519: 100.00		PDIA2_HUMAN (27-128): 9.25e-21: 96.8: 24.30
+	At
		137900 CALR1_ARATH (7-359): 4.51e-150: 433: 54.34		PDI21_ARATH (30-283): 3.25e-40: 149: 23.74
+	Dm
		667020 CALR_DROME (4-406): 7.43e-167: 475: 66.58		Q3YMU0_DROME (14-130): 1.21e-22: 102: 31.15
+	Hs
		671897 CALR3_HUMAN (1-362): 1.5e-165: 471: 51.38		PDIA3_HUMAN (14-136): 6.09e-23: 103: 30.47
+	Hs
		531950 CALR3_HUMAN (1-362): 1.5e-165: 471: 51.38		PDIA4_HUMAN (10-130): 1.56e-21: 99.5: 25.20
+	Hs
		423330 CALR3_HUMAN (1-362): 1.5e-165: 471: 51.38		PDIA1_HUMAN (23-128): 2.75e-21: 98.3: 29.73
+	Dm
		667013 CALR_DROME (4-406): 7.43e-167: 475: 66.58		PDI_DROME (23-127): 1.75e-18: 89.5: 27.52
+	Hs
		1240407 CALR3_HUMAN (1-362): 1.5e-165: 471: 51.38		TXND5_HUMAN (45-125): 7.66e-12: 68.9: 37.81
+	Hs
		654099 CALX_HUMAN (20-416): 1.51e-145: 428: 34.39		PDIA3_HUMAN (14-136): 6.09e-23: 103: 30.47
+	Hs
		531729 CALX_HUMAN (20-416): 1.51e-145: 428: 34.39		PDIA4_HUMAN (10-130): 1.56e-21: 99.5: 25.20
+	Hs
		423150 CALX_HUMAN (20-416): 1.51e-145: 428: 34.39		PDIA1_HUMAN (23-128): 2.75e-21: 98.3: 29.73