HitPredict

Interactor 1: PEP3 (P27801)
Vacuolar membrane protein PEP3 (Carboxypeptidase Y-deficient protein 3) (Vacuolar morphogenesis protein 8) (Vacuolar protein sorting-associated protein 18) (Vacuolar protein-targeting protein 18)
Gene: PEP3

Interactor 2: YPT7 (P32939)
Ypt/Rab-type GTPase YPT7 (Ypt7p) (Vacuolar morphology protein 4)
Gene: YPT7

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	10944212, 33513092
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000329 - fungal-type vacuole membrane GO:0005829 - cytosol GO:0008333 - endosome to lysosome transport GO:0032889 - regulation of vacuole fusion, non-autophagic
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 918 Sc			1 208
+	Hs
		845311 VPS18_HUMAN (175-916): 0: 553: 21.75		RAB7A_HUMAN (1-208): 8.09e-90: 263: 61.91
+	Hs
		914418 VPS18_HUMAN (175-916): 0: 553: 21.75		RB11A_HUMAN (2-208): 2.49e-72: 220: 29.17
+	Hs
		845782 VPS18_HUMAN (175-916): 0: 553: 21.75		RAB9A_HUMAN (5-208): 5.19e-61: 190: 48.53
+	Hs
		845237 VPS11_HUMAN (320-885): 2.45e-110: 363: 14.36		RAB7A_HUMAN (1-208): 8.09e-90: 263: 61.91
+	Hs
		845170 VPS39_HUMAN (279-854): 3.74e-101: 337: 13.93		RAB7A_HUMAN (1-208): 8.09e-90: 263: 61.91
+	Hs
		914349 VPS11_HUMAN (320-885): 2.45e-110: 363: 14.36		RB11A_HUMAN (2-208): 2.49e-72: 220: 29.17
+	Hs
		845725 VPS11_HUMAN (320-885): 2.45e-110: 363: 14.36		RAB9A_HUMAN (5-208): 5.19e-61: 190: 48.53
+	Dm
		284082 VPS39_DROME (270-861): 1.47e-81: 284: 13.48		RAB7_DROME (1-208): 3.71e-87: 257: 58.10
+	Hs
		845067 VPS8_HUMAN (281-856): 1.68e-75: 272: 11.23		RAB7A_HUMAN (1-208): 8.09e-90: 263: 61.91
+	Hs
		833138 VPS41_HUMAN (373-860): 4.28e-76: 268: 13.28		RAB7A_HUMAN (1-208): 8.09e-90: 263: 61.91
+	Hs
		914209 VPS8_HUMAN (281-856): 1.68e-75: 272: 11.23		RB11A_HUMAN (2-208): 2.49e-72: 220: 29.17
+	Sc
		701775 VPS41_YEAST (271-825): 8.52e-70: 252: 11.61		YPT7_YEAST (1-208): 1.11e-78: 235: 100.00
+	Sc
		522447 PEP5_YEAST (315-856): 8.96e-67: 244: 12.62		YPT7_YEAST (1-208): 1.11e-78: 235: 100.00
+	Hs
		845603 VPS8_HUMAN (281-856): 1.68e-75: 272: 11.23		RAB9A_HUMAN (5-208): 5.19e-61: 190: 48.53
+	Sc
		701815 VAM6_YEAST (430-835): 6.98e-50: 193: 14.04		YPT7_YEAST (1-208): 1.11e-78: 235: 100.00
+	Zm
		7871 A0A1D6EJH5_MAIZE (338-801): 6.4e-09: 62.2: 9.11		A0A1D6FTA4_MAIZE (1-206): 1.27e-73: 223: 53.05
+	Zm
		25302 A0A1D6IQ85_MAIZE (338-800): 8.81e-09: 61.8: 8.92		A0A1D6M9Y7_MAIZE (1-206): 2.03e-72: 220: 54.76