HitPredict

Interactor 1: PEP3 (P27801)
Vacuolar membrane protein PEP3 (Carboxypeptidase Y-deficient protein 3) (Vacuolar morphogenesis protein 8) (Vacuolar protein sorting-associated protein 18) (Vacuolar protein-targeting protein 18)
Gene: PEP3

Interactor 2: YPT52 (P36018)
GTP-binding protein YPT52
Gene: YPT52

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	21325627
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000329 - fungal-type vacuole membrane GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0006895 - Golgi to endosome transport
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 918 Sc			1 234
+	Hs
		914418 VPS18_HUMAN (175-916): 0: 553: 21.75		RB11A_HUMAN (4-233): 2.3e-73: 223: 33.33
+	Hs
		592546 VPS18_HUMAN (175-916): 0: 553: 21.75		RAB5A_HUMAN (3-234): 3.63e-56: 179: 46.35
+	Dm
		1097257 VPS18_DROME (174-917): 1.53e-167: 516: 20.44		RAB5_DROME (3-233): 1.83e-59: 188: 50.22
+	Hs
		914349 VPS11_HUMAN (320-885): 2.45e-110: 363: 14.36		RB11A_HUMAN (4-233): 2.3e-73: 223: 33.33
+	Hs
		592486 VPS11_HUMAN (320-885): 2.45e-110: 363: 14.36		RAB5A_HUMAN (3-234): 3.63e-56: 179: 46.35
+	Hs
		844647 TGFA1_HUMAN (269-868): 2.12e-86: 297: 11.82		RAB5C_HUMAN (3-234): 1.58e-79: 239: 46.55
+	Hs
		844615 VPS8_HUMAN (281-856): 1.68e-75: 272: 11.23		RAB5C_HUMAN (3-234): 1.58e-79: 239: 46.55
+	Hs
		914209 VPS8_HUMAN (281-856): 1.68e-75: 272: 11.23		RB11A_HUMAN (4-233): 2.3e-73: 223: 33.33
+	Sc
		731215 VPS41_YEAST (271-825): 8.52e-70: 252: 11.61		YPT52_YEAST (1-234): 2.89e-76: 231: 100.00
+	Sc
		522449 PEP5_YEAST (315-856): 8.96e-67: 244: 12.62		YPT52_YEAST (1-234): 2.89e-76: 231: 100.00
+	Dm
		1358736 VPS8_DROME (303-862): 1.08e-72: 263: 10.94		RAB5_DROME (3-233): 1.83e-59: 188: 50.22
+	Hs
		592367 VPS8_HUMAN (281-856): 1.68e-75: 272: 11.23		RAB5A_HUMAN (3-234): 3.63e-56: 179: 46.35
+	Sc
		522448 PEP5_YEAST (315-856): 8.96e-67: 244: 12.62		VPS21_YEAST (5-232): 5.97e-57: 181: 48.25
+	Sc
		731236 VAM6_YEAST (430-835): 6.98e-50: 193: 14.04		YPT52_YEAST (1-234): 2.89e-76: 231: 100.00
+	Sc
		731206 VAM6_YEAST (430-835): 6.98e-50: 193: 14.04		VPS21_YEAST (5-232): 5.97e-57: 181: 48.25
+	Sc
		731216 VPS8_YEAST (496-863): 1.17e-10: 68: 11.06		YPT52_YEAST (1-234): 2.89e-76: 231: 100.00
+	Sc
		731174 VPS8_YEAST (496-863): 1.17e-10: 68: 11.06		VPS21_YEAST (5-232): 5.97e-57: 181: 48.25
+	Sc
		731245 VPS8_YEAST (496-863): 1.17e-10: 68: 11.06		YPT53_YEAST (2-193): 3.18e-54: 175: 53.13