HitPredict

Interactor 1: PEP3 (P27801)
Vacuolar membrane protein PEP3 (Carboxypeptidase Y-deficient protein 3) (Vacuolar morphogenesis protein 8) (Vacuolar protein sorting-associated protein 18) (Vacuolar protein-targeting protein 18)
Gene: PEP3

Interactor 2: VPS8 (P39702)
Vacuolar protein sorting-associated protein 8 (Vacuolar protein-targeting protein 8)
Gene: VPS8

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.750

Property	Details
Experiments	11805826, 16429126, 21325627, 23840658, 23417307, 37968396, 20604902
Identification Methods	tandem affinity purification, affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030897 - HOPS complex GO:0031901 - early endosome membrane GO:0032889 - regulation of vacuole fusion, non-autophagic GO:0033263 - CORVET complex GO:0046872 - metal ion binding and 1 others more... GO:0099022 - vesicle tethering
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 918 Sc			1 1274
+	Sc
		758407 VPS41_YEAST (271-825): 8.52e-70: 252: 11.61		VPS8_YEAST (1-1274): 0: 1966: 100.00
+	Sc
		522454 PEP5_YEAST (315-856): 8.96e-67: 244: 12.62		VPS8_YEAST (1-1274): 0: 1966: 100.00
+	Sc
		763455 VAM6_YEAST (430-835): 6.98e-50: 193: 14.04		VPS8_YEAST (1-1274): 0: 1966: 100.00
+	Hs
		1232473 VPS18_HUMAN (175-916): 0: 553: 21.75		VPS8_HUMAN (521-1269): 0: 651: 19.17
+	Dm
		1097263 VPS18_DROME (174-917): 1.53e-167: 516: 20.44		VPS8_DROME (514-1268): 0: 577: 21.04
+	Hs
		1232471 VPS11_HUMAN (320-885): 2.45e-110: 363: 14.36		VPS8_HUMAN (521-1269): 0: 651: 19.17
+	Hs
		1232463 TGFA1_HUMAN (269-868): 2.12e-86: 297: 11.82		VPS8_HUMAN (521-1269): 0: 651: 19.17
+	Ce
		59454 A3QMB3_CAEEL (281-883): 4.62e-11: 69.1: 10.89		A3QMB3_CAEEL (520-1264): 0: 661: 15.99