HitPredict

Interactor 1: PEP3 (P27801)
Vacuolar membrane protein PEP3 (Carboxypeptidase Y-deficient protein 3) (Vacuolar morphogenesis protein 8) (Vacuolar protein sorting-associated protein 18) (Vacuolar protein-targeting protein 18)
Gene: PEP3

Interactor 2: VAM3 (Q12241)
Syntaxin VAM3 (Vacuolar morphogenesis protein 3)
Gene: VAM3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.721

Property	Details
Experiments	14662743, 11030345, 23051737, 15889152, 28148647
Identification Methods	coimmunoprecipitation, pull down, affinity chromatography technology
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000329 - fungal-type vacuole membrane GO:0006886 - intracellular protein transport GO:0042144 - vacuole fusion, non-autophagic
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 918 Sc			1 283
+	Sc
		653825 PEP3_YEAST (1-918): 0: 955: 100.00		TLG2_YEAST (5-281): 7.77e-41: 147: 17.42
+	Mm
		1206466 VPS18_MOUSE (175-916): 0: 558: 21.49		Q8BH40_MOUSE (16-281): 2.41e-55: 181: 22.47
+	Mm
		192855 VPS18_MOUSE (175-916): 0: 558: 21.49		STX1A_MOUSE (19-282): 3.95e-53: 176: 14.02
+	Hs
		1084004 VPS18_HUMAN (175-916): 0: 553: 21.75		STX1A_HUMAN (19-282): 5.88e-53: 176: 14.02
+	Rn
		78216 B5DFJ4_RAT (175-916): 0: 560: 21.49		STX7_RAT (16-264): 1.48e-49: 166: 22.00
+	Mm
		1246840 VPS18_MOUSE (175-916): 0: 558: 21.49		STX12_MOUSE (1-264): 2.99e-47: 160: 17.23
+	Rn
		78214 B5DFJ4_RAT (175-916): 0: 560: 21.49		STX12_RAT (1-264): 1.93e-46: 158: 17.23
+	Hs
		178829 VPS18_HUMAN (175-916): 0: 553: 21.75		STX7_HUMAN (16-281): 3.4e-47: 160: 21.72
+	Dm
		1097264 VPS18_DROME (174-917): 1.53e-167: 516: 20.44		Q9VU45_DROME (13-283): 6.41e-15: 74.9: 18.38
+	Mm
		1206467 VPS11_MOUSE (320-885): 4.49e-112: 368: 14.36		Q8BH40_MOUSE (16-281): 2.41e-55: 181: 22.47
+	Rn
		88722 D3ZTB4_RAT (320-885): 7.91e-113: 370: 14.87		STX1A_RAT (19-282): 5.17e-53: 176: 13.64
+	Mm
		192856 VPS11_MOUSE (320-885): 4.49e-112: 368: 14.36		STX1A_MOUSE (19-282): 3.95e-53: 176: 14.02
+	Hs
		1083988 VPS11_HUMAN (320-885): 2.45e-110: 363: 14.36		STX1A_HUMAN (19-282): 5.88e-53: 176: 14.02
+	Hs
		178771 VPS11_HUMAN (320-885): 2.45e-110: 363: 14.36		STX7_HUMAN (16-281): 3.4e-47: 160: 21.72
+	Hs
		1017756 VPS39_HUMAN (279-854): 3.74e-101: 337: 13.93		STX4_HUMAN (10-281): 1.22e-40: 144: 12.73
+	Hs
		178659 VPS8_HUMAN (281-856): 1.68e-75: 272: 11.23		STX7_HUMAN (16-281): 3.4e-47: 160: 21.72
+	Sc
		758430 VPS41_YEAST (271-825): 8.52e-70: 252: 11.61		VAM3_YEAST (1-283): 1.17e-40: 144: 100.00
+	Sc
		522472 PEP5_YEAST (315-856): 8.96e-67: 244: 12.62		VAM3_YEAST (1-283): 1.17e-40: 144: 100.00
+	Sc
		991355 VAM6_YEAST (430-835): 6.98e-50: 193: 14.04		VAM3_YEAST (1-283): 1.17e-40: 144: 100.00
+	Sc
		699200 VPS8_YEAST (496-863): 1.17e-10: 68: 11.06		PEP12_YEAST (11-261): 7.81e-16: 77.6: 19.31