HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: PTN6 (P29350)
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)
Gene: PTPN6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 1.00 0.870

The method score is based on:

Property Details
Experiments 9452499, 11160222, 10488096
Identification Methods far western blotting, affinity chromatography technology, pull down, two hybrid, coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PI3K_P85_iSH2~SH2, SH2~Y_phosphatase
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005911 - cell-cell junction
and 2 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 724
Hs

1 595
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024