HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.965

The method score is based on:

Property Details
Experiments 19889638, 16135792, 16219545, 7537361, 19380743, 9541596, 8621719, 8662998
Identification Methods affinity chromatography technology, pull down, tandem affinity purification, coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PI3K_P85_iSH2~SH2
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158 - insulin receptor binding
GO:0005159 - insulin-like growth factor receptor binding
GO:0005168 - neurotrophin TRKA receptor binding
and 5 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 724
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024