HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: LTK (P29376)
Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)
Gene: LTK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	9223670, 8084603, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 864
+	Hs
		655504 P85A_HUMAN (1-724): 0: 596: 100.00		ALK_HUMAN (4-851): 0: 701: 54.51
+	Hs
		434140 P85A_HUMAN (1-724): 0: 596: 100.00		RET_HUMAN (278-849): 5.71e-146: 461: 25.98
+	Hs
		600513 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA1_HUMAN (25-817): 9.44e-137: 433: 19.11
+	Hs
		601463 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR2_HUMAN (163-833): 6.48e-137: 429: 20.03
+	Hs
		609182 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR3_HUMAN (100-834): 2.96e-137: 429: 20.99
+	Hs
		655377 P85A_HUMAN (1-724): 0: 596: 100.00		ERBB4_HUMAN (277-847): 5.2e-131: 425: 21.37
+	Hs
		435546 P85A_HUMAN (1-724): 0: 596: 100.00		IGF1R_HUMAN (298-854): 3.35e-128: 419: 27.39
+	Hs
		655222 P85A_HUMAN (1-724): 0: 596: 100.00		EPHB2_HUMAN (391-796): 1.67e-127: 410: 26.21
+	Hs
		411306 P85A_HUMAN (1-724): 0: 596: 100.00		INSR_HUMAN (367-837): 3.2e-121: 400: 30.82
+	Hs
		655220 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA3_HUMAN (388-798): 3.64e-124: 400: 27.30
+	Hs
		655284 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA5_HUMAN (389-809): 8.73e-124: 400: 26.02
+	Hs
		507870 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42
+	Hs
		655219 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA2_HUMAN (446-813): 2.21e-109: 360: 30.38
+	Hs
		655389 P85A_HUMAN (1-724): 0: 596: 100.00		NTRK2_HUMAN (475-778): 2.43e-61: 224: 38.07
+	Hs
		384316 P85A_HUMAN (1-724): 0: 596: 100.00		NTRK1_HUMAN (502-786): 7.75e-60: 220: 41.64
+	Hs
		561382 P85A_HUMAN (1-724): 0: 596: 100.00		FER_HUMAN (505-777): 7.62e-58: 214: 41.03
+	Hs
		426946 P85A_HUMAN (1-724): 0: 596: 100.00		FES_HUMAN (509-778): 3.14e-57: 213: 42.96
+	Hs
		655387 P85A_HUMAN (1-724): 0: 596: 100.00		NTRK3_HUMAN (502-778): 1.77e-54: 205: 36.76
+	Hs
		655320 P85A_HUMAN (1-724): 0: 596: 100.00		ROR1_HUMAN (504-778): 1.86e-53: 202: 40.00
+	Hs
		655253 P85A_HUMAN (1-724): 0: 596: 100.00		TXK_HUMAN (504-774): 3.82e-53: 195: 37.82