HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: IRS1 (P35568)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.769

The method score is based on:

Property Details
Experiments 25814554, 17640984, 26839216, 16880210, 16230374, 1334490, 7935461, 1381348, 8175658, 9564850, 8628286, 30240640, 29526746, 25273559, 7659087, 8388384, 12173038, 12730242, 12107746, 33991522 and 16 others

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Identification Methods affinity chromatography technology, pull down, far western blotting, two hybrid, unspecified method, biophysical, two hybrid array, luminescence based mammalian interactome mapping, validated two hybrid, anti bait coimmunoprecipitation and 6 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158 - insulin receptor binding
GO:0005159 - insulin-like growth factor receptor binding
GO:0005634 - nucleus
and 10 others

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Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 724
Hs

1 1242
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Last updated: 15 Jul 2024