HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: PK3CA (P42336)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
Gene: PIK3CA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.994

The method score is based on:

Property Details
Experiments 27684187, 9235916, 26839216, 24657164, 19805105, 28205554, 34831026, 35755276, 34591612, 20713702, 26496610, 11526404, 19117013, 26475863, 7957566, 9565634, 15932879, 7929193, 33420362, 35271311 and 13 others

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Identification Methods affinity chromatography technology, x-ray crystallography, fluorescent resonance energy transfer, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type physical association, association, direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains PI3K_P85_iSH2~PI3_PI4_kinase, PI3K_C2~PI3K_P85_iSH2, PI3K_P85_iSH2~PI3K_p85B, PI3K_P85_iSH2~PI3Ka, PI3_PI4_kinase~SH2, PI3K_C2~SH2, PI3Ka~SH2
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005942 - phosphatidylinositol 3-kinase complex
GO:0005943 - phosphatidylinositol 3-kinase complex, class IA
and 9 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 724
Hs

1 1068
+ Bt
+ Mm
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+ Mm
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+ Dm
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024