HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: PTEN (P60484)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
Gene: PTEN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	20212113, 34831026
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0043491 - phosphatidylinositol 3-kinase/protein kinase B signal transduction and 1 others more... GO:0050821 - protein stabilization
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 403
+	Hs
		129257 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		PTEN_HUMAN (1-403): 4.63e-168: 478: 100.00
+	Hs
		890718 SRGP1_HUMAN (86-631): 1.15e-53: 202: 11.88		PTEN_HUMAN (1-403): 4.63e-168: 478: 100.00
+	Hs
		433303 YES_HUMAN (568-724): 2.15e-31: 131: 20.61		PTEN_HUMAN (1-403): 4.63e-168: 478: 100.00