HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 196
+	Hs
		655307 P85A_HUMAN (1-724): 0: 596: 100.00		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Mm
		643072 P85A_MOUSE (1-724): 0: 592: 95.99		RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10
+	Hs
		655297 P85A_HUMAN (1-724): 0: 596: 100.00		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		545215 P85A_HUMAN (1-724): 0: 596: 100.00		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		436167 P85A_HUMAN (1-724): 0: 596: 100.00		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		655316 P85A_HUMAN (1-724): 0: 596: 100.00		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		655294 P85A_HUMAN (1-724): 0: 596: 100.00		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		655295 P85A_HUMAN (1-724): 0: 596: 100.00		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		564419 P85A_HUMAN (1-724): 0: 596: 100.00		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		120309 P85A_HUMAN (1-724): 0: 596: 100.00		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		129270 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		129262 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		129267 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		129190 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		129275 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		129259 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		129260 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		129193 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		120196 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		564631 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74