HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: ROR2 (Q01974)
Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2)
Gene: ROR2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 943
+	Hs
		655320 P85A_HUMAN (1-724): 0: 596: 100.00		ROR1_HUMAN (41-942): 0: 678: 56.94
+	Hs
		601463 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR2_HUMAN (18-804): 9.32e-172: 522: 19.65
+	Hs
		507870 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR1_HUMAN (18-803): 1.13e-169: 517: 18.90
+	Hs
		609182 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR3_HUMAN (34-805): 8.14e-166: 506: 19.04
+	Hs
		607886 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR4_HUMAN (36-796): 2.55e-151: 468: 20.75
+	Hs
		655230 P85A_HUMAN (1-724): 0: 596: 100.00		UFO_HUMAN (28-837): 6.67e-148: 462: 19.23
+	Hs
		434140 P85A_HUMAN (1-724): 0: 596: 100.00		RET_HUMAN (254-846): 1.68e-140: 449: 21.89
+	Mm
		643062 P85A_MOUSE (1-724): 0: 592: 95.99		RET_MOUSE (254-846): 1.45e-138: 444: 21.23
+	Hs
		655377 P85A_HUMAN (1-724): 0: 596: 100.00		ERBB4_HUMAN (139-924): 3.66e-135: 439: 20.89
+	Hs
		655328 P85A_HUMAN (1-724): 0: 596: 100.00		TYRO3_HUMAN (18-839): 5.45e-136: 431: 18.71
+	Hs
		655387 P85A_HUMAN (1-724): 0: 596: 100.00		NTRK3_HUMAN (259-755): 4.11e-127: 406: 28.91
+	Hs
		655366 P85A_HUMAN (1-724): 0: 596: 100.00		FAK2_HUMAN (429-864): 6.44e-113: 372: 29.00
+	Hs
		655325 P85A_HUMAN (1-724): 0: 596: 100.00		FAK1_HUMAN (358-850): 2.55e-110: 367: 27.18
+	Hs
		655285 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA4_HUMAN (370-779): 6.97e-110: 364: 33.01
+	Hs
		655389 P85A_HUMAN (1-724): 0: 596: 100.00		NTRK2_HUMAN (465-753): 4.36e-111: 363: 44.29
+	Mm
		643057 P85A_MOUSE (1-724): 0: 592: 95.99		FAK1_MOUSE (358-837): 1.37e-109: 364: 27.50
+	Hs
		384316 P85A_HUMAN (1-724): 0: 596: 100.00		NTRK1_HUMAN (478-748): 6.27e-66: 238: 43.91
+	Hs
		411306 P85A_HUMAN (1-724): 0: 596: 100.00		INSR_HUMAN (467-747): 2.53e-53: 204: 39.15
+	Hs
		655222 P85A_HUMAN (1-724): 0: 596: 100.00		EPHB2_HUMAN (466-746): 4.25e-53: 203: 40.70
+	Hs
		435546 P85A_HUMAN (1-724): 0: 596: 100.00		IGF1R_HUMAN (467-747): 1.28e-51: 199: 37.68